The Assess-AI Registry provides monitoring of algorithm performance in clinical practice by capturing real-world data during clinical use. Assess-AI combines specific information related to an algorithm’s effectiveness reported by radiologists at the point of care, as well as specific metadata related to the exam as specified in Define-AI use cases. Metadata includes information such as equipment manufacturer, magnetic field strength or number of CT detectors and other relevant examination parameters, as well as relevant demographic data about the patient. Together these provide Assess-AI with a unique pathway for measuring algorithm performance in real-world settings.